Breakthrough on Cell
Peroxisome Proliferator Activated Receptors (PPARs) with Resveratrol was first isolated from the roots of white hellebore (Veratrum grandiflorum O. Loes) in 1940, and later in 1963 from the roots of Polygonum cuspidatum, a plant used in traditional medicine. In 1992, resveratrol from red grape skin was found to have cardio protective effects. Since then, resveratrol become the most actively studied molecules. Series of studies revealed that resveratrol can slow or protect the progression of a wide variety of illness, including cardiovascular diseases, stroke, as well as enhance stress resistance.
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Peroxisome Proliferator Activated Receptors (PPARs) are a group of nuclear receptor proteins that function as transcription factors regulating the expression of genes. PPARs play essential roles in the regulation of cellular differentiation, development, and metabolism (carbohydrate, lipid, and protein) of higher organisms.